Anacondas: Trail of Blood, (also known as Anaconda 4, Anaconda 4: Trail of Blood and Anacondas 4: Trail of Blood), is a 2009 made-for-television horror film and sequel to Anaconda 3: Offspring. Written by David C. Olson and directed by Don E. FauntLeRoy, it is the fourth and currently final film in the Anaconda series and picks up where the third film ended. It premiered on the Sci Fi Channel on February 28, 2009, and was released to DVD June 2, 2009.
A baby anaconda, captured at the end of Anaconda 3: Offspring, is being used for experiments by a scientist. He creates a hybrid of the blood orchids from Borneo that enabled the anaconda to grow so large and live so long, and creates a serum for cell regeneration. When he disappears and the snake escapes, Murdoch, a billionaire suffering from bone cancer, sends a team to find him (Eugene leading Jackie, Leila, Hakeem, and Armon) and the serum because that serum can cure him. He also tells them to be careful of Dr. Amanda Hayes, and to kill her if needed. Dr. Amanda Hayes and two officers also go in search of the scientist, determined to destroy the serum and kill the snake…
“Just have some people run around the woods being chased be a big CGI snake that bears little resemblance to an actual anaconda for 90 minutes and give little regard to the plodding pace or drowsy plotting. The best the film has to offer is an amusing wide angle silhouette side shot of the snake slithering after an unlucky soul through a field. Everything else before and after that one inspired scene feels like stale leftovers from every other generic killer snake flick the Sci-Fi Channel has churned out over the years.” Dread Central
“Trashy, idiotic, badly written, terribly directed and utterly devoid of quality, it’s probably not a surprise that Anacondas 4 is a despicable mess, but it’s barely even entertaining.” Gorepress